A multimodal evaluation of microstructural white matter damage in spinocerebellar ataxia type 3.
Identifieur interne : 000B32 ( Main/Exploration ); précédent : 000B31; suivant : 000B33A multimodal evaluation of microstructural white matter damage in spinocerebellar ataxia type 3.
Auteurs : Rachel P. Guimarães [Brésil] ; Anelyssa D'Abreu ; Clarissa L. Yasuda ; Marcondes C. França ; Beatriz H B. Silva ; Fabio A M. Cappabianco ; Felipe P G. Bergo ; Iscia T. Lopes-Cendes ; Fernando CendesSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Anisotropy, Brain Mapping, Case-Control Studies, Cluster Analysis, Diffusion Tensor Imaging, Female, Humans, Imaging, Three-Dimensional, Leukoencephalopathies (complications), Leukoencephalopathies (pathology), Machado-Joseph Disease (complications), Machado-Joseph Disease (pathology), Male, Middle Aged, Nerve Fibers, Myelinated (pathology), Severity of Illness Index.
- MESH :
- complications : Leukoencephalopathies, Machado-Joseph Disease.
- pathology : Leukoencephalopathies, Machado-Joseph Disease, Nerve Fibers, Myelinated.
- Adult, Aged, Anisotropy, Brain Mapping, Case-Control Studies, Cluster Analysis, Diffusion Tensor Imaging, Female, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Severity of Illness Index.
Abstract
Although white matter damage may play a major role in the pathogenesis of spinocerebellar ataxia 3 (SCA3), available data rely exclusively upon macrostructural analyses. In this setting we designed a study to investigate white matter integrity. We evaluated 38 genetically-confirmed SCA3 patients (mean age, 52.76 ± 12.70 years; 21 males) with clinical scales and brain magnetic resonance imaging (MRI) and 38 healthy subjects as a control group (mean age, 48.86 ± 12.07 years, 20 male). All individuals underwent the same protocol for high-resolution T1 and T2 images and diffusion tensor imaging acquisition (32 directions) in a 3-T scanner. We used Tract-Based Spatial Statistics (FSL 4.1.4) to analyze diffusion data and SPM8/DARTEL for voxel-based morphometry of infratentorial structures. T2-relaxometry of cerebellum was performed with in-house-developed software Aftervoxel and Interactive Volume Segmentation (IVS). Patients' mean age at onset was 40.02 ± 11.48 years and mean duration of disease was 9.3 ± 2.7 years. Mean International Cooperative Ataxia Rating Scale (ICARS) and Scale for Assessment and Rating of Ataxia (SARA) scores were 32.08 ± 4.01 and 14.65 ± 7.33, respectively. Voxel-based morphometry demonstrated a volumetric reduction of gray and white matter in cerebellum and brainstem (P <.001). We found reduced fractional anisotropy (P <.05) in the cerebellum and brainstem. There were also areas of increased radial diffusivity (P <.05) in the cerebellum, brainstem, thalamus, frontal lobes, and temporal lobes. In addition, we found decreased T2-relaxation values in the white matter of the right cerebellar hemisphere. Microstructural white matter dysfunction, not previously reported, occurs in the cerebellum and brainstem of SCA3 patients.
DOI: 10.1002/mds.25451
PubMed: 23553599
Affiliations:
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França</name></author><author><name sortKey="Silva, Beatriz H B" sort="Silva, Beatriz H B" uniqKey="Silva B" first="Beatriz H B" last="Silva">Beatriz H B. Silva</name></author><author><name sortKey="Cappabianco, Fabio A M" sort="Cappabianco, Fabio A M" uniqKey="Cappabianco F" first="Fabio A M" last="Cappabianco">Fabio A M. Cappabianco</name></author><author><name sortKey="Bergo, Felipe P G" sort="Bergo, Felipe P G" uniqKey="Bergo F" first="Felipe P G" last="Bergo">Felipe P G. Bergo</name></author><author><name sortKey="Lopes Cendes, Iscia T" sort="Lopes Cendes, Iscia T" uniqKey="Lopes Cendes I" first="Iscia T" last="Lopes-Cendes">Iscia T. Lopes-Cendes</name></author><author><name sortKey="Cendes, Fernando" sort="Cendes, Fernando" uniqKey="Cendes F" first="Fernando" last="Cendes">Fernando Cendes</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anisotropy</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Cluster Analysis</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Leukoencephalopathies (complications)</term><term>Leukoencephalopathies (pathology)</term><term>Machado-Joseph Disease (complications)</term><term>Machado-Joseph Disease (pathology)</term><term>Male</term><term>Middle Aged</term><term>Nerve Fibers, Myelinated (pathology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Leukoencephalopathies</term><term>Machado-Joseph Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Leukoencephalopathies</term><term>Machado-Joseph Disease</term><term>Nerve Fibers, Myelinated</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anisotropy</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Cluster Analysis</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although white matter damage may play a major role in the pathogenesis of spinocerebellar ataxia 3 (SCA3), available data rely exclusively upon macrostructural analyses. In this setting we designed a study to investigate white matter integrity. We evaluated 38 genetically-confirmed SCA3 patients (mean age, 52.76 ± 12.70 years; 21 males) with clinical scales and brain magnetic resonance imaging (MRI) and 38 healthy subjects as a control group (mean age, 48.86 ± 12.07 years, 20 male). All individuals underwent the same protocol for high-resolution T1 and T2 images and diffusion tensor imaging acquisition (32 directions) in a 3-T scanner. We used Tract-Based Spatial Statistics (FSL 4.1.4) to analyze diffusion data and SPM8/DARTEL for voxel-based morphometry of infratentorial structures. T2-relaxometry of cerebellum was performed with in-house-developed software Aftervoxel and Interactive Volume Segmentation (IVS). Patients' mean age at onset was 40.02 ± 11.48 years and mean duration of disease was 9.3 ± 2.7 years. Mean International Cooperative Ataxia Rating Scale (ICARS) and Scale for Assessment and Rating of Ataxia (SARA) scores were 32.08 ± 4.01 and 14.65 ± 7.33, respectively. Voxel-based morphometry demonstrated a volumetric reduction of gray and white matter in cerebellum and brainstem (P <.001). We found reduced fractional anisotropy (P <.05) in the cerebellum and brainstem. There were also areas of increased radial diffusivity (P <.05) in the cerebellum, brainstem, thalamus, frontal lobes, and temporal lobes. In addition, we found decreased T2-relaxation values in the white matter of the right cerebellar hemisphere. Microstructural white matter dysfunction, not previously reported, occurs in the cerebellum and brainstem of SCA3 patients.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><noCountry><name sortKey="Bergo, Felipe P G" sort="Bergo, Felipe P G" uniqKey="Bergo F" first="Felipe P G" last="Bergo">Felipe P G. Bergo</name><name sortKey="Cappabianco, Fabio A M" sort="Cappabianco, Fabio A M" uniqKey="Cappabianco F" first="Fabio A M" last="Cappabianco">Fabio A M. Cappabianco</name><name sortKey="Cendes, Fernando" sort="Cendes, Fernando" uniqKey="Cendes F" first="Fernando" last="Cendes">Fernando Cendes</name><name sortKey="D Abreu, Anelyssa" sort="D Abreu, Anelyssa" uniqKey="D Abreu A" first="Anelyssa" last="D'Abreu">Anelyssa D'Abreu</name><name sortKey="Franca, Marcondes C" sort="Franca, Marcondes C" uniqKey="Franca M" first="Marcondes C" last="França">Marcondes C. França</name><name sortKey="Lopes Cendes, Iscia T" sort="Lopes Cendes, Iscia T" uniqKey="Lopes Cendes I" first="Iscia T" last="Lopes-Cendes">Iscia T. Lopes-Cendes</name><name sortKey="Silva, Beatriz H B" sort="Silva, Beatriz H B" uniqKey="Silva B" first="Beatriz H B" last="Silva">Beatriz H B. Silva</name><name sortKey="Yasuda, Clarissa L" sort="Yasuda, Clarissa L" uniqKey="Yasuda C" first="Clarissa L" last="Yasuda">Clarissa L. Yasuda</name></noCountry><country name="Brésil"><region name="État de São Paulo"><name sortKey="Guimaraes, Rachel P" sort="Guimaraes, Rachel P" uniqKey="Guimaraes R" first="Rachel P" last="Guimarães">Rachel P. Guimarães</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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